Harmonize the sign orientation of omic-layer effects

Some omic measurements have an interpretation whose natural direction is opposite to an activity/abundance scale used in other layers. This helper multiplies selected omic effects by +1 or -1 and applies the corresponding sign transformation to covariance matrices. Use it only when the orientation is scientifically justified; it must not be used to force apparent agreement.

Usage

orient_omics(effects, covariance = NULL, orientation)

Arguments

effects

Effect table with `omic` and `effect` columns.

covariance

Optional OmicsBraid covariance object or named covariance list.

orientation

Named numeric vector with one value (+1 or -1) per omic to be re-oriented. Omics not named default to +1.

Value

A list with oriented `effects` and `covariance`.